Description

Mesothelin (MSLN). It plays a role in cell adhesion.


Clinical trials

NCT02792114 - Breast Cancer
NCT03356795 - Cervical Cancer
NCT04503980 – Colorectal Cancer, Ovarian Cancer
NCT03638206 – Colorectal Cancer, Esophagus Cancer, Renal Carcinoma, Hepatoma, Lung Cancer, Mesothelioma, Ovarian Cancer, Pancreatic Cancer, Melanoma
NCT03941626 – Esophagus Cancer, Hepatoma
NCT02959151 – Hepatoma
NCT03054298 - Lung Adenocarcinoma, Ovarian Cancer
NCT04489862 - Mesothelioma
NCT02580747 – Mesothelioma, Ovarian Cancer, Pancreatic Cancer, Endometrial Cancer
NCT03814447 – Ovarian Cancer
NCT03497819 – Pancreatic Cancer
NCT03323944 - Pancreatic Cancer
NCT03638193 - Pancreatic Cancer
NCT02706782 - Pancreatic Cancer
NCT02465983 - Pancreatic Cancer
NCT03267173 - Pancreatic Cancer


Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene MSLN.


Target essentiality


Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present.